A database of hormones and their receptors
Home
Hormone
Receptor
Tools
Miscellaneous
Contact
Peptide Hormone

Search Result - 1

HMRbase accession number10739
Swiss-prot Accession numberP01245 (Sequence in FASTA format)
DescriptionSomatotropin precursor (Growth hormone).
Source organismEquus caballus (Horse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the somatotropin/prolactin family.
Tissue SpecificityN/A
Post translational modification N/A
Function Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length216 Amino acids
Molecular weight24423
References1  PubMed abstract 8206392
2  PubMed abstract 965151
3  PubMed abstract 4747849
4  PubMed abstract 11946725
5  PubMed abstract 4876100
Domain NameHormone_1  
Hormone NameGrowth hormone (Somatotropin) (GH)
Mature Hormone SequenceFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDMELLRFSLLLIQSWLGPVQLLSRVFTNSLVFGTSDRVYEKLRDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
Position of mature hormone in Pre-Hormone protein190 Residues from position (27-216)
ReceptorN/A
Gene ID100034180      
PDB IDN/A
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated


Search Result - 2

HMRbase accession number10771
Swiss-prot Accession numberO62754 (Sequence in FASTA format)
DescriptionSomatotropin precursor (Growth hormone).
Source organismTrichosurus vulpecula (Brush-tailed possum)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Metatheria; Diprotodontia; Phalangeridae; Trichosurus.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the somatotropin/prolactin family.
Tissue SpecificityN/A
Post translational modification N/A
Function Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length215 Amino acids
Molecular weight24353
References1  PubMed abstract 9653023
Domain NameHormone_1  
Hormone NameGrowth hormone (Somatotropin) (GH)
Mature Hormone SequenceFPAMPLSSLFANAVLRAQHLHQLVADTYKEFERTYIPEAQRHSIQSTQTAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLSPVQFLSRVFTNSLVFGTSDRVYEKLRDLEEGIQALMQELEDGSSRGGLVLKTTYDKFDTNLRSDEALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
Position of mature hormone in Pre-Hormone protein190 Residues from position (26-215)
ReceptorN/A
Gene IDN/A
PDB IDN/A
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated


Search Result - 3

HMRbase accession number11319
Swiss-prot Accession numberP01241 (Sequence in FASTA format)
DescriptionSomatotropin precursor (Growth hormone) (GH) (GH-N) (Pituitary growthhormone) (Growth hormone 1).
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the somatotropin/prolactin family.
Tissue SpecificityN/A
Post translational modification N/A
Function Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length217 Amino acids
Molecular weight24847
References1  PubMed abstract 386281
2  PubMed abstract 377496
3  PubMed abstract 6269091
4  PubMed abstract 7169009
5  PubMed abstract 2744760
6   Gu J., Huang Q.-H., Li N., Xu S.-H., Han Z.-G., Fu G., Chen Z.; "A novel gene expressed in human pituitary."; Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
7  PubMed abstract 10931946
8  PubMed abstract 15489334
9  PubMed abstract 3912261
10  PubMed abstract 5810834
11  PubMed abstract 5144027
12  PubMed abstract 4675454
13  PubMed abstract 5279046
14  PubMed abstract 5279528
15   Niall H.D.; "The chemistry of the human lactogenic hormones."; (In) Griffiths K. (eds.);Prolactin and carcinogenesis, Proc. fourth tenovus workshop prolactin,pp.13-20, Alpha Omega Alpha Press, Cardiff (1972).
16  PubMed abstract 7462247
17  PubMed abstract 7356479
18  PubMed abstract 7028740
19  PubMed abstract 14997482
20  PubMed abstract 10393484
21  PubMed abstract 16807684
22  PubMed abstract 3447173
23  PubMed abstract 1549776
24  PubMed abstract 7984244
25   Chantalat L., Chirgadze N.Y., Jones N., Korber F., Navaza J.,Pavlovsk A.G., Wlodawer A.; "The crystal-structure of wild-type growth-hormone at 2.5-Aresolution."; Protein Pept. Lett. 2:333-340(1995).
26  PubMed abstract 8943276
27  PubMed abstract 8552145
28   Takahashi Y., Kaji H., Okimura Y., Goji K., Abe H., Chihara K.; N. Engl. J. Med. 334:1207-1207(1996).
29  PubMed abstract 9276733
30  PubMed abstract 10391209
31   Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999).
32  PubMed abstract 11502836
33  PubMed abstract 12655557
Domain NameHormone_1  
Hormone NameGrowth hormone (Somatotropin) (GH)
Mature Hormone SequenceFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Position of mature hormone in Pre-Hormone protein191 Residues from position (27-217)
ReceptorP10912    Detail in HMRbase   
Gene ID2688      
PDB ID1A22   1AXI   1BP3   1HGU   1HUW   1HWG   1HWH   1KF9   3HHR      
Drugpediawiki
Comments


Search Result - 4

HMRbase accession number11320
Swiss-prot Accession numberP01244 (Sequence in FASTA format)
DescriptionSomatotropin precursor (Growth hormone).
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the somatotropin/prolactin family.
Tissue SpecificityN/A
Post translational modification N/A
Function Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length216 Amino acids
Molecular weight24656
References1  PubMed abstract 6272224
2  PubMed abstract 339105
3  PubMed abstract 6946433
4  PubMed abstract 8521139
Domain NameHormone_1  
Hormone NameGrowth hormone (Somatotropin) (GH)
Mature Hormone SequenceFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKEEAQQRTDMELLRFSLLLIQSWLGPVQFLSRIFTNSLMFGTSDRVYEKLKDLEEGIQALMQELEDGSPRIGQILKQTYDKFDANMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFAESSCAF
Position of mature hormone in Pre-Hormone protein190 Residues from position (27-216)
ReceptorP16310    Detail in HMRbase   
Gene ID24391      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 5

HMRbase accession number11321
Swiss-prot Accession numberP01246 (Sequence in FASTA format)
DescriptionSomatotropin precursor (Growth hormone).
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the somatotropin/prolactin family.
Tissue SpecificityN/A
Post translational modification N/A
FunctionPlays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length217 Amino acids
Molecular weight24558
References1  PubMed abstract 6893197
2  PubMed abstract 6296767
3  PubMed abstract 6303731
4  PubMed abstract 6357899
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6   Mauro S.M.Z., Ferro M.I.T., Macari M., Ferro J.A.; "The complete sequence of a cDNA encoding the bovine growth hormone."; Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
7   Javadmanesh A., Nassiry M., Eftekhari Shahrudi F., Basami M.; "Cloning the cDNA of bovine growth hormone gene in E. coli."; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
8  PubMed abstract 4584625
9  PubMed abstract 4580883
10  PubMed abstract 3899556
11  PubMed abstract 4856718
12  PubMed abstract 5579941
13  PubMed abstract 1123321
14  PubMed abstract 2021631
Domain NameHormone_1  
Hormone NameGrowth hormone (Somatotropin) (GH)
Mature Hormone SequenceAFPAMSLSGLFANAVLRAQHLHQLAADTFKEFERTYIPEGQRYSIQNTQVAFCFSETIPAPTGKNEAQQKSDLELLRISLLLIQSWLGPLQFLSRVFTNSLVFGTSDRVYEKLKDLEEGILALMRELEDGTPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFRKDLHKTETYLRVMKCRRFGEASCAF
Position of mature hormone in Pre-Hormone protein191 Residues from position (27-217)
ReceptorO46600    Detail in HMRbase   
Gene ID280804      
PDB ID1BST      
Drugpediawiki
Comments


Search Result - 6

HMRbase accession number11322
Swiss-prot Accession numberP01248 (Sequence in FASTA format)
DescriptionSomatotropin precursor (Growth hormone).
Source organismSus scrofa (Pig)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the somatotropin/prolactin family.
Tissue SpecificityN/A
Post translational modification N/A
Function Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues
Protein Length216 Amino acids
Molecular weight24429
References1  PubMed abstract 3666458
2  PubMed abstract 2182128
3  PubMed abstract 2491309
4  PubMed abstract 4918150
5  PubMed abstract 6303731
6  PubMed abstract 1343826
7   Jiang Z.H., Rottmann O.J., Pirchner F.; Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
Domain NameHormone_1  
Hormone NameGrowth hormone (Somatotropin) (GH)
Mature Hormone SequenceFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
Position of mature hormone in Pre-Hormone protein190 Residues from position (27-216)
ReceptorP19756    Detail in HMRbase   
Gene IDN/A
PDB IDN/A
Drugpediawiki
Comments